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Editors-in-Chief: Eugene V Koonin, National Center for Biotechnology Information, NIH; Laura F Landweber, Princeton University; David J Lipman, National Center Biotechnology Information, NIH

Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in selected subject areas, and will eventually cover the full spectrum of biology.

Subject areas already launched include:
- Genomics, Bioinformatics and Systems Biology - Edited by Eugene Koonin, Laura Landweber, & David Lipman
- Immunology - Edited by Neil S Greenspan & David R Kaplan
- Mathematical Biology - Edited by Marek Kimmel.

Submit your manuscript online.


In 2009, to commemorate the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the "Origin of Species", Biology Direct plans to publish a thematic series dedicated to the current state of evolutionary biology, under the general heading "Evolutionary Biology 150 years after the 'Origin': is a post-modern synthesis in sight?" The series will consist of a number of critical reviews and discussion articles that will investigate and assess today's understanding of evolution at all levels, the fate of the legacy of Darwin and the modern synthesis, and the goals and prospects for the next half-century. Original contributions with broad implications and extended discussion will be considered as well. It is expected that many of these articles will address the evolutionary implications of genomics and systems biology but all aspects of evolutionary biology are within the scope of this series.

 

Proposals are welcome. These should contain an extended summary of the article and, ideally, a list of key references, and should be emailed to Eugene Koonin. The deadline for proposal submission is July 1, 2009.

Latest articles

Hypothesis    
Retention of the virus-derived sequences in the nuclear genome of grapevine as a potential pathway to virus resistance
Christophe Bertsch, Monique Beuve, Valerian V. Dolja, Marion Wirth, Frederique Pelsy, Etienne Herrbach, Olivier Lemaire
Biology Direct 2009, 4:21 (26 June 2009)
[Abstract] [Provisional PDF] [PubMed] [Related articles]




Research    
γ-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates
Da-Peng Wang, Hao-Lei Wan, Song Zhang, Jun Yu
Biology Direct 2009, 4:20 (16 June 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]




Research    
Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes
Kira S Makarova, Yuri I Wolf, Eugene V Koonin
Biology Direct 2009, 4:19 (3 June 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]




Discovery notes    
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites
Sebastian Maurer-Stroh, Jianmin Ma, Raphael Tze Chuen Lee, Fernanda L Sirota, Frank Eisenhaber
Biology Direct 2009, 4:18 (20 May 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Sequence variation analysis and 3D modeling of the 2009 H1N1 influenza virus indicate that antiviral drugs currently in use should remain effective for treatment.



Hypothesis    
Chaotic expression dynamics implies pluripotency: when theory and experiment meet
Chikara Furusawa, Kunihiko Kaneko
Biology Direct 2009, 4:17 (15 May 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Quantitative characterization using theoretical and experimental evidence suggests that chaotic oscillation in gene expression can induce the restoration of stem cell pluripotency.



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 ISSN: 1745-6150



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