Biology Direct

Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in selected subject areas, and will eventually cover the full spectrum of biology.

Subject areas already launched include:

Genomics, Bioinformatics and Systems Biology - Edited by Eugene Koonin, Laura Landweber, & David Lipman.
Immunology - Edited by Neil S Greenspan & David R Kaplan.
Mathematical Biology - Edited by Marek Kimmel.

Editors-in-Chief

Eugene Koonin, NCBI, NLM, NIH
Laura Landweber, Princeton University
David Lipman, NCBI, NLM, NIH

Editorial Board | Instructions for authors | FAQ

Articles

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Hypothesis

Primordial soup or vinaigrette: did the RNA world evolve at acidic pH?

Bernhardt HS and Tate WP Biology Direct 2012, 7:4 (20 January 2012)

The greater stability of key RNA bonds at acidic pH, such as link the phosphodiester backbone and between amino acids and tRNA, suggests the RNA world evolved in acidic conditions.
Research

IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice

Greenspan NS, Lu MA, Shipley JW, Ding X, Li Q, Sultana D, Kollaros M, Schreiber JR et al. Biology Direct 2012, 7:3 (16 January 2012)

In MRL/lpr mice, which spontaneously develop autoimmune glomerulonephritis like that in systemic lupus erythematosus, genetic elimination of IgG3 antibody production diminishes renal pathology and extends lifespan.
Research

On the Molecular Mechanism of GC Content Variation among Eubacterial Genomes

Wu H, Zhang Z, Hu S and Yu J Biology Direct 2012, 7:2 (10 January 2012)

New large-scale comparative genome analyses provided further evidences indicating that polymerases involved in either replication or repair pathways underlie the GC content variability in eubacteria.
Research

Evolution before genes

Vasas V, Fernando C, Santos M, Kauffman S and Szathmary E Biology Direct 2012, 7:1 (5 January 2012)
Research

CRISPR loci reveal networks of gene exchange in archaea

Brodt A, Lurie-Weinberger MN and Gophna U Biology Direct 2011, 6:65 (21 December 2011)
Research

Accurate State Estimation from Uncertain Data and Models: An Application of Data Assimilation to Mathematical Models of Human Brain Tumors

Kostelich EJ, Kuang Y, McDaniel JM, Moore NZ, Martirosyan NL and Preul MC Biology Direct 2011, 6:64 (21 December 2011)

State estimation schemes, employed operationally for weather forecasting, can be applied in principle to make useful short-term predictions of the growth and spread of malignant tumors in individual patient cases.
Research

Purine biosynthesis in archaea: variations on a theme

Brown AM, Hoopes SL, White RH and Sarisky CA Biology Direct 2011, 6:63 (14 December 2011)
Research

The existence of species rests on a metastable equilibrium between inbreeding and outbreeding.

Joly E Biology Direct 2011, 6:62 (9 December 2011)

A model whereby new species arise by budding from the ancestral stock rather than by splitting into separate populations, with advantageous recessive phenotypes promoting the direct selection of reproductive barriers.
Research

Transcription factor binding sites are highly enriched within microRNA precursor sequences

Piriyapongsa J, Jordan IK, Conley AB, Ronan T and Smalheiser NR Biology Direct 2011, 6:61 (2 December 2011)
Research

On universal common ancestry, sequence similarity, and phylogenetic structure: The sins of P-values and the virtues of Bayesian evidence

Theobald DL Biology Direct 2011, 6:60 (24 November 2011)

Douglas Theobald, in response to recent criticisms, provides evidence to further support his claim that Darwin's hypothesis that all life on earth has a universal common ancestor has been formally confirmed by a homology independent statistic test.
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Comments

Yeast Standards

Comment on: Cartwright et al. Biology Direct 2011, 6:7
Article mis-states the yeast convention

Comment on: Cartwright et al. Biology Direct 2011, 6:7
I am suppose that PyrD polarization in this article is...

Comment on: Valas et al. Biology Direct 2010, 4:30

Unique model of peer review

Biology Direct offers a novel system of peer review, allowing authors to select suitable reviewers from the journal's Editorial Board; making the peer-review process open rather than anonymous; and making the reviewers' reports public, thus increasing the responsibility of the referees and eliminating sources of abuse in the refereeing process.