Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in subject areas currently identified as those most conducive to the open review approach, primarily those with a significant non-experimental component.
Editors-in-Chief
- Eugene Koonin, NCBI, NLM, NIH
- Laura Landweber, Princeton University
- David Lipman, NCBI, NLM, NIH
Articles
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Editorial
Biology Direct 2013, 8:11 (30 April 2013)Biology direct: celebrating 7 years of open, published peer review -
Research
Biology Direct 2013, 8:10 (24 April 2013)Genome-wide analysis reveals downregulation of miR-379/miR-656 cluster in human cancers
The large miRNA cluster on human chromosome 14q32.31 is implicated as a tumor suppressor locus with possible coordinated function – revealed by comprehensive analysis of the Cancer Genome Atlas data supported by experiments
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Research
Biology Direct 2013, 8:9 (22 April 2013)Insights into archaeal evolution and symbiosis from the genomes of a nanoarchaeon and its inferred crenarchaeal host from Obsidian Pool, Yellowstone National Park
The genome of the first terrestrial member of the Nanoarchaeota and comparisons with the marine Nanoarchaeum equitans reveals stages in the evolution of archaeal symbiosis and parasitism
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Review
Biology Direct 2013, 8:8 (4 April 2013)Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life
Striking similarity between cell invasiveness mechanisms in plants and metazoans, including pathological conditions such as invasive cancer, opens possibilities for interdispciplinary transfer of findings related to invasive cell growth.
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Research
Biology Direct 2013, 8:7 (22 March 2013)Invariance and optimality in the regulation of an enzyme
In Michaelis-Menten kinetics, metabolite production depends on the average, but not on the dynamical changes, of the catalyzing enzyme, thus enabling the analytical identification of enzyme trajectories with minimal cost.
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Discovery notes
Biology Direct 2013, 8:6 (12 February 2013)Description of plant tRNA-derived RNA fragments (tRFs) associated with argonaute and identification of their putative targets
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Discovery notes
Biology Direct 2013, 8:5 (7 February 2013)GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia
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Discovery notes
Biology Direct 2013, 8:4 (28 January 2013)Surprisingly high number of Twintrons in vertebrates
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Highly scalable phylogenomic approaches are needed to make evolutionary sense of the ongoing deluge of sequence data; these approaches can be free from multiple sequence alignment.
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Research
Analysis of a large sequence dataset from the thermotolerant hydrothermal vent annelid Alvinella pompejana identified the CvP-bias as a robust measure of thermostability in eukaryotes.
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Unique model of peer review
Biology Direct offers a novel system of peer review, allowing authors to select suitable reviewers from the journal's Editorial Board; making the peer-review process open rather than anonymous; and making the reviewers' reports public, thus increasing the responsibility of the referees and eliminating sources of abuse in the refereeing process.
Thematic series
Beyond the tree of life
Edited by Dr Maureen O'Malley and Dr Yan Boucher
Published: 30 June 2011
Evolution and cancer: A mathematical biology approach
Edited by Prof Marek Kimmel
Published: 20 April 2010
Evolutionary Biology 150 years after the 'Origin': is a post-modern synthesis in sight?
Edited by Dr Eugene Koonin
Published: 24 April 2009
Origin and early evolution of life
Edited by Dr Eugene Koonin
Published: 9 July 2008
View all article series
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