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Items 1 - 20 of 95
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1:

Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection.

Glazko GV, Babenko VN, Koonin EV, Rogozin IB.

Biol Direct. 2006 Jan 31;1:4.

PMID: 16542006 [PubMed]

2:

Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis.

Babenko VN, Basu MK, Kondrashov FA, Rogozin IB, Koonin EV.

BMC Cancer. 2006 Feb 9;6:36.

PMID: 16469093 [PubMed - indexed for MEDLINE]

3:

Theoretical analysis of mutation hotspots and their DNA sequence context specificity.

Rogozin IB, Pavlov YI.

Mutat Res. 2003 Sep;544(1):65-85. Review.

PMID: 12888108 [PubMed - indexed for MEDLINE]

4:

p53 gain-of-function: tumor biology and bioinformatics come together.

Koonin EV, Rogozin IB, Glazko GV.

Cell Cycle. 2005 May;4(5):686-8. Epub 2005 May 28.

PMID: 15846083 [PubMed - indexed for MEDLINE]

5:

Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.

Walsh T, Casadei S, Coats KH, Swisher E, Stray SM, Higgins J, Roach KC, Mandell J, Lee MK, Ciernikova S, Foretova L, Soucek P, King MC.

JAMA. 2006 Mar 22;295(12):1379-88.

PMID: 16551709 [PubMed - indexed for MEDLINE]

6:

BRCA1 and TP53 mutation spectrum of breast carcinoma in an ethnic population of Kashmir, an emerging high-risk area.

Eachkoti R, Hussain I, Afroze D, Aejazaziz S, Jan M, Shah ZA, Das BC, Siddiqi MA.

Cancer Lett. 2007 Apr 18;248(2):308-20. Epub 2006 Sep 22.

PMID: 16996204 [PubMed - indexed for MEDLINE]

7:

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.

Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, Olivier M.

Hum Mutat. 2007 Jun;28(6):622-9.

PMID: 17311302 [PubMed - indexed for MEDLINE]

8:

Unique substitution of CHEK2 and TP53 mutations implicated in primary prostate tumors and cancer cell lines.

Zheng L, Wang F, Qian C, Neumann RM, Cheville JC, Tindall DJ, Liu W.

Hum Mutat. 2006 Oct;27(10):1062-3.

PMID: 16941491 [PubMed - indexed for MEDLINE]

9:

iMARS--mutation analysis reporting software: an analysis of spontaneous cII mutation spectra.

Morgan C, Lewis PD.

Mutat Res. 2006 Jan 31;603(1):15-26. Epub 2005 Dec 15.

PMID: 16359913 [PubMed - indexed for MEDLINE]

10:

Widespread positive selection in synonymous sites of mammalian genes.

Resch AM, Carmel L, Mariño-Ramírez L, Ogurtsov AY, Shabalina SA, Rogozin IB, Koonin EV.

Mol Biol Evol. 2007 Aug;24(8):1821-31. Epub 2007 May 23.

PMID: 17522087 [PubMed - indexed for MEDLINE]

11:

Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers.

Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Abdelmohsen K, Gorospe M, Kern SE.

Cell Cycle. 2006 May;5(10):1090-3. Epub 2006 May 15.

PMID: 16721048 [PubMed - indexed for MEDLINE]

12:

Novel hotspot detector software reveals a non-CpG hotspot of germline mutation in the factor IX gene (F9) in Latin Americans.

Drost JB, Scaringe WA, Jaloma-Cruz AR, Li X, Ossa DF, Kasper CK, Sommer SS.

Hum Mutat. 2000 Sep;16(3):203-10.

PMID: 10980527 [PubMed - indexed for MEDLINE]

13:

Towards realistic codon models: among site variability and dependency of synonymous and non-synonymous rates.

Mayrose I, Doron-Faigenboim A, Bacharach E, Pupko T.

Bioinformatics. 2007 Jul 1;23(13):i319-27.

PMID: 17646313 [PubMed - indexed for MEDLINE]

14:

Significance of CpG methylation for solar UV-induced mutagenesis and carcinogenesis in skin.

Ikehata H, Ono T.

Photochem Photobiol. 2007 Jan-Feb;83(1):196-204. Review.

PMID: 16620158 [PubMed - indexed for MEDLINE]

15:

Silent mutations in the gene encoding the p53 protein are preferentially located in conserved amino acid positions and splicing enhancers.

Lamolle G, Marin M, Alvarez-Valin F.

Mutat Res. 2006 Aug 30;600(1-2):102-12. Epub 2006 May 2.

PMID: 16650445 [PubMed - indexed for MEDLINE]

16:

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes.

Petitjean A, Achatz MI, Borresen-Dale AL, Hainaut P, Olivier M.

Oncogene. 2007 Apr 2;26(15):2157-65. Review.

PMID: 17401424 [PubMed - indexed for MEDLINE]

17:

Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.

Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, Broderick S, Sarkaria IS, Pham D, Singh B, Miner TL, Fewell GA, Fulton LL, Mardis ER, Wilson RK, Kris MG, Rusch VW, Varmus H, Pao W.

PLoS ONE. 2007 May 9;2(5):e426.

PMID: 17487277 [PubMed]

18:

Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature.

Gu D, Scaringe WA, Li K, Saldivar JS, Hill KA, Chen Z, Gonzalez KD, Sommer SS.

Hum Mutat. 2007 Aug;28(8):760-70.

PMID: 17429853 [PubMed - indexed for MEDLINE]

20:

Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.

Mounawar M, Mukeria A, Le Calvez F, Hung RJ, Renard H, Cortot A, Bollart C, Zaridze D, Brennan P, Boffetta P, Brambilla E, Hainaut P.

Cancer Res. 2007 Jun 15;67(12):5667-72.

PMID: 17575133 [PubMed - indexed for MEDLINE]

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