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Eugene V Koonin,
National Center for Biotechnology Information, NIH;
Laura F Landweber,
Princeton University;
David J Lipman,
National Center Biotechnology Information, NIH
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 Welcome to Biology Direct
  An online journal published by BioMed Central

Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in selected subject areas, and will eventually cover the full spectrum of biology. Subject areas already launched include Genomics, Bioinformatics and Systems Biology, Immunology, and Mathematical Biology.

Biology Direct aims to provide authors and readers of research articles with a novel system of peer review. This will include making the author responsible for obtaining reviewers' reports, via the journal's Editorial Board; making the peer review process open rather than anonymous; and publishing the reviewers' reports along with the articles, thus increasing both the responsibility and the reward of the referees and eliminating sources of abuse in the refereeing process. See 'about Biology Direct' and the Biology Direct instructions for authors for further information.

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Latest articles

Research    
A family of GFP-like proteins with different spectral properties in lancelet Branchiostoma floridae
Diana Baumann, Malcolm Cook, Limei Ma, Arcady Mushegian, Erik Sanders, Joel Schwartz, C RON Yu
Biology Direct 2008, 3:28 (3 July 2008)
[Abstract] [Provisional PDF]




Research    
Detection of co-eluted peptides using database search methods
Gelio Alves, Aleksey Y Ogurtsov, Siwei Kwok, Wells W Wu, Guanghui Wang, Rong-Fong Shen, Yi-Kuo Yu
Biology Direct 2008, 3:27 (2 July 2008)
[Abstract] [Provisional PDF]

The "one peptide per spectrum" dogma cannot hold true due to limited chromatographic separation resulting in mass spectra containing co-eluted peptides with high probability; this issue is numerically investigated.



Research    
Complete genome sequence of the extremely acidophilic methanotroph isolate V4, "Methylacidiphilum infernorum", a representative of the bacterial phylum Verrucomicrobia
Shaobin Hou, Kira S. Makarova, Jimmy H. W Saw, Pavel Senin, Benjamin V. Ly, Zhemin Zhou, Yan Ren, Jianmei Wang, Michael Y. Galperin, Marina V. Omelchenko, Yuri I. Wolf, Natalya Yutin, Eugene V. Koonin, Matthew B. Stott, Bruce W. Mountain, Michelle A. Crowe, Angela V. Smirnova, Peter F. Dunfield, Lu Feng, Lei Wang, Maqsudul Alam
Biology Direct 2008, 3:26 (1 July 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Genome sequence of a methanotrophic member of the bacterial phylum Verrucomicrobia reveals adaptations to the methane utilization under acidic conditions and supports grouping Planctomycetes, Verrucomicrobia and Chlamydiae into a superphylum



Research    
Genetic characterization of Hawaiian isolates of Plasmodium relictum reveals mixed-genotype infections
Susan I Jarvi, Margaret EM Farias, Carter T Atkinson
Biology Direct 2008, 3:25 (25 June 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

High clonal diversity of introduced avian malaria in native Hawaiian forest birds adds complexity to this disease system with potential impacts on transmission, host-pathogen interactions and virulence.



Research    
In Silico regulatory analysis for exploring human disease progression
Dustin T Holloway, Mark Kon, Charles DeLisi
Biology Direct 2008, 3:24 (18 June 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Machine learning methods are employed to predict targets of transcription factors in the human genome and further provide possible insights on Wt1 and its role in Wilms Tumor.



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