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Genome factor and gene pleiotropy hypotheses in protein evolution

Yanwu Zeng and Xun Gu*

Biology Direct 2010, 5:37 doi:10.1186/1745-6150-5-37

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Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins

Humberto Peralta, Gabriela Guerrero, Alejandro Aguilar, Jaime Mora Biology Direct 2011, 6:48 (4 October 2011)

Diversification of orthologous genes provokes specific physico-chemical changes in proteins of related species, revealing particular trends required to perform their functional roles in the adaptation to niche and intra-cellular conditions.