Table 1 |
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|
Constants and values used in model |
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|
Constant |
Value |
Reference |
|
|
||
|
H+ diffusion coefficient |
1.08 × 10-5 cm2/s |
[24] |
|
O2 diffusion coefficient |
1.46 × 10-5 cm2/s |
[25] |
|
Glucose diffusion coefficient |
5 × 10-6 cm2/s |
[26] |
|
O2 uptake rate |
9.41 × 10-2 × [O2]/s |
[27] |
|
Glucose uptake rate |
5 × 10-5 × [Glc]/s |
[24] |
|
Quiescence pH threshold for normal cells |
7.1 |
[28] |
|
Death pH threshold for normal cells |
6.8 |
[28] |
|
Mutation rate for tumor cells |
0.1% |
[28] |
|
ATP production for 100% probability of cell duplication. |
8.6 × 10-6 M/s |
[29] |
|
Minimum ATP production for cell survival. |
8.6 × 10-7 M/s |
[29] |
|
|
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|
Silva and Gatenby Biology Direct 2010 5:25 doi:10.1186/1745-6150-5-25 |
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