Research
Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules
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* Corresponding author: Ralf Dressel rdresse@gwdg.de
- † Equal contributors
Biology Direct 2009, 4:31 doi:10.1186/1745-6150-4-31
An early warning against rejection-free claim for iPS cells
Shi Liu (2009-09-04 09:53) Eagle Institute of Molecular Medicine
I have been wondering why almost all the transplantations of iPSCs (induced pluripotent stem cells) were done on SCID mice rather than on normal mice. As a matter of fact I even publicly questioned the study design of a study and asked: Why a study aimed at showing a "circumvention of the immune rejection barrier" by using iPSC-based therapy would still use sub-lethally irradiated mice as the recipients? (see publication at http://im1.biz/displayimage.php?album=84&pos=1 ).
I think the results presented here should serve as a warning against many naive claims for cell therapy. Immunity may be more tricky than we have thought of and reprogramming cells may even present or expose some antigens subject to rejection reactions.
Competing interests
None
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