Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

doi:10.1186/1745-6150-4-29

Biology Direct

Volume 4

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Hypothesis

Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

Kira S Makarova¹ , Yuri I Wolf¹ , John van der Oost² and Eugene V Koonin¹

¹National Center for Biotechnology Information, NLM, National Institutes of Health, Bethesda, Maryland 20894, USA

²Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, Netherlands

author email corresponding author email

Biology Direct 2009, 4:29doi:10.1186/1745-6150-4-29


Published:	25 August 2009

Additional files

Additional file 1:

The list of all identified PIWI domain containing proteins and their closest neighborhood. The data provided represent list of all identified PIWI domain containing proteins that were further analyzed in this work.

Format: XLS Size: 654KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 2:

Multiple alignment for full length PIWI domain containing proteins. The provided alignment shows distinct group of PIWI proteins.

Format: ALI Size: 157KB Download file

Additional file 3:

Multiple alignment of uncharacterized C-terminal domain of proteins also containing N-terminal nuclease domain and associated with PIWI proteins. The provided alignment shows the previously undetected domain associated with PIWI proteins.

Format: ALI Size: 20KB Download file

Additional file 4:

Multiple alignment of uncharacterized N-terminal domain of proteins also containing C-terminal nuclease domain and associated with PIWI proteins. The provided alignment shows the previously undetected domain associated with PIWI proteins.

Format: ALI Size: 4KB Download file

Additional file 5:

The list of all COGs implicated in antiphage defense. The data provided represent list of phage defense COGs of four distinct systems used for the Fisher Omnibus test.

Format: XLS Size: 491KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 6:

The data used for the Fisher Omnibus test. The file contains data and calculations for the Fisher Omnibus test. Each worksheet corresponds to the analysis of a distinct set of phage defense COGs (see also AF3_Ph_def_COGs.xls). On the left hand side are calculations for the whole set of genome. On the right hand side, highlighted in yellow, calculations for a representative set of genomes (closely related genomes were excluded).

Format: XLS Size: 109KB Download file

This file can be viewed with: Microsoft Excel Viewer