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Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

Kira S Makarova, Yuri I Wolf, John van der Oost and Eugene V Koonin*

Biology Direct 2009, 4:29 doi:10.1186/1745-6150-4-29

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Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

Kira S Makarova, L Aravind, Yuri I Wolf, Eugene V Koonin Biology Direct 2011, 6:38 (14 July 2011)

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The origin and early evolution of eukaryotes in the light of phylogenomics

Eugene V Koonin Genome Biology 2010, 11:209 (5 May 2010)

This article is part of a collection on 10th Anniversary...

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Comparative genomics and new phylogenies of eukaryote groups suggest a scenario in which the mitochondrial endosymbiosis triggered the origin of eukaryotes.

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