Biology Direct

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γ-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates

Da-Peng Wang1,2, Hao-Lei Wan1,2, Song Zhang1,2,3 and Jun Yu1,3*

Author Affiliations

1 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, PR China

2 Graduate University of Chinese Academy of Sciences, Beijing 100039, PR China

3 Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, PR China

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Biology Direct 2009, 4:20 doi:10.1186/1745-6150-4-20

Published: 16 June 2009

Additional files

Additional file 1:

Standard deviations of ω and supplementary method. Additional file 1 contains: (I) the standard deviations of ω values that are used in Figure 1, Figure 2, Figure 4, Figure 5 and Table 4; (II) human codon and rice codon frequencies; and (III) an approach of determining the optimal α values in each test.

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Additional file 2:

Description of the Tamura-Nei model and the detailed derivations of κR and κY. Additional file 2 contains supplementary tables and derivation process in this study. This file contains two sections: section I shows the description of the Tamura-Nei model and section II details the procedures for deducing κR and κY.

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