Deciphering peculiar protein-protein interacting modules in Deinococcus radiodurans

doi:10.1186/1745-6150-4-12

Biology Direct

Volume 4

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Deciphering peculiar protein-protein interacting modules in Deinococcus radiodurans

Karim Mezhoud , Haïtham Sghaier and Insaf Barkallah

Unit of Microbiology and Molecular Biology, National Center for Nuclear Sciences and Technologies (CNSTN), Sidi Thabet Technopark, 2020, Ariana, Tunisia

author email corresponding author email

Biology Direct 2009, 4:12doi:10.1186/1745-6150-4-12


Published:	8 April 2009

Abstract

Interactomes of proteins under positive selection from ionizing-radiation-resistant bacteria (IRRB) might be a part of the answer to the question as to how IRRB, particularly Deinococcus radiodurans R₁(Deira), resist ionizing radiation. Here, using the Database of Interacting Proteins (DIP) and the Protein Structural Interactome (PSI)-base server for PSI map, we have predicted novel interactions of orthologs of the 58 proteins under positive selection in Deira and other IRRB, but which are absent in IRSB. Among these, 18 domains and their interactomes have been identified in DNA checkpoint and repair; kinases pathways; energy and nucleotide metabolisms were the important biological processes that were found to be involved. This finding provides new clues to the cellular pathways that can to be important for ionizing-radiation resistance in Deira.