Research

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

Tahir H Tahirov¹^*, Kira S Makarova², Igor B Rogozin², Youri I Pavlov¹ and Eugene V Koonin²^*

* Corresponding authors: Tahir H Tahirov ttahirov@unmc.edu - Eugene V Koonin koonin@ncbi.nlm.nih.gov

¹ Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-7696, USA

² National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

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Biology Direct 2009, 4:11 doi:10.1186/1745-6150-4-11

Published: 18 March 2009

Additional file 1:

Multiple alignment of Exo-Pol modules of B-family DdDps (text).

Format: TXT Size: 114KB Download file

Additional file 2:

Phylogenetic trees of B-family DdDps (in Newick format) constructed with different methods (text).

Format: TXT Size: 13KB Download file