Research
Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code
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* Corresponding author: Harold S Bernhardt berha498@student.otago.ac.nz
Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
Biology Direct 2008, 3:53 doi:10.1186/1745-6150-3-53
Published: 17 December 2008Additional files
Additional file 1:
Post-transcriptional modification of tRNAs from E. coli, H. volcanii and S. cerevisiae. Three (almost) complete sets of tRNA sequences with characterised modifications from Escherichia coli (bacteria), Haloferax volcanii (archaea) and Saccharomyces cerevisiae (eukaryote cytoplasm) were selected from the Compilation of tRNA sequences and sequences of tRNA genes from [13]. The order of their proposed utilization within the genetic code with their specific amino acids [9] is plotted against the number of post-transcriptionally modified nucleotides. (A) The percentage of tRNA sequences with a modified nucleotide in position 37. (B) The average total number of modified nucleotides in the tRNA molecule. The sequence sets included in the analysis contained between one and five tRNAs from an individual species and between three and twelve tRNAs from all three species. Note: the values for glutamine were not included due to the absence from the database of a sequence(s) from S. cerevisiae.
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