Table 1

The three-residue grip model of susceptibility to immune mediated diabetes
allele
 β9
 β37
 Non-Asp β57
 score
 T1D
DRB1*0101
 Hydrophobic W
 Polar S
 No
 1
 No
DRB1*0301
 Polar E
 Polar N
 No
 2
 Yes
DRB1*0401
 Polar E
 Polar Y
 No
 2
 Yes
DRB1*0402
 Polar E
 Polar Y
 No
 2
 Yes
DRB1*0403
 Polar E
 Polar Y
 No
 2
 No
DRB1*0404
 Polar E
 Polar Y
 No
 2
 Yes
DRB1*0405
 Polar E
 Polar Y
 Yes S
 3
 Yes
DRB1*0406
 Polar E
 Polar S
 No
 2
 No
DRB1*0407
 Polar E
 Polar Y
 No
 2
 Yes
DRB1*0408
 Polar E
 Polar E
 No
 2
 Yes
DRB1*0409
 Polar E
 Polar Y
 Yes S
 3
 Yes
DRB1*07
 Hydrophobic W
 Hydrophobic F
 Yes V
 1
 No
DRB1*0801
 Polar E
 Polar Y
 Yes S
 3
 Yes
DRB1*0901
 Charged K
 Polar N
 Yes V
 3
 Yes
DRB1*1001
 Polar E
 Polar Y
 No
 2
 No
DRB1*11
 Polar E
 Polar Y/N/S/D
 No
 2
 Yes
DRB1*11
 Polar E
 Hydrophobic, F
 No
 1
 No
DRB1*12
 Polar E
 Hydrophobic L/F
 Yes V
 2
 No
DRB1*1301
 Polar E
 Polar N
 No
 2
 Yes
DRB1*1303
 Polar E
 Polar Y
 Yes S
 3
 Yes
DRB1*1401
 Polar E
 Hydrophobic F
 Yes A
 2
 No
DRB1*1402
 Polar E
 Polar N
 No
 2
 No
DRB1*15
 Hydrophobic W
 Polar S
 No
 1
 No
DRB1*16
 Hydrophobic W
 Polar S
 No
 1
 No
DRB3*0101
 Polar E
 Hydrophobic F
 Yes V
 2
 No
DRB3*0200
 Polar E
 Polar Y
 No
 2
 Yes
DRB5*0202
 Polar Q
 Polar D/N
 No
 2
 Yes
DQB1*05
 Polar Y
 Polar Y
 Yes V
 3
 Yes
DQB1*0201
 Polar Y
 Hydrophobic I
 Yes A
 2
 Yes
DQB1*0301
 Polar Y
 Polar Y
 No
 2
 Yes
DQB1*0302
 Polar Y
 Polar Y
 Yes A
 3
 Yes
DQB1*0303
 Polar Y
 Polar Y
 No
 2
 Yes
DQB1*0601
 Hydrophobic L
 Polar D
 No
 1
 No
DQB1*0602
 Hydrophobic F
 Polar Y
 No
 1
 No
DQB1*0603
 Polar Y
 Polar Y
 No
 2
 No
DQB1*0604
 Polar Y
 Polar Y
 Yes V
 3
 Yes

Polymorphic residues within pocket P9 of class II MHC alleles are scored according to whether they are polar/charged (+1), hydrophobic (0) or whether the conserved β57 aspartic acid is replaced (+1). A replacement at β57 Asp leaves α76 Arg free to coordinate an acidic peptide anchor in P9, or when the pocket is hydrophobic move out of the pocket. Two polar residues in the pocket or a polar residue and β57 aspartic acid mutation distinguishes between alleles that predispose to diabetes and those that do not with few exceptions. Diabetes association in column 6 is culled from the published literature. DR11 is listed both as a susceptibility allele and as a resistant (neutral) allele. Typing was to two significant figures; this obscures the nature of residue at β37.

Parry and Brooks Biology Direct 2008 3:42   doi:10.1186/1745-6150-3-42

Open Data