Biology Direct

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Comparable contributions of structural-functional constraints and expression level to the rate of protein sequence evolution

Maxim Y Wolf, Yuri I Wolf and Eugene V Koonin*

Biology Direct 2008, 3:40 doi:10.1186/1745-6150-3-40

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Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins

Humberto Peralta, Gabriela Guerrero, Alejandro Aguilar, Jaime Mora Biology Direct 2011, 6:48 (4 October 2011)

Diversification of orthologous genes provokes specific physico-chemical changes in proteins of related species, revealing particular trends required to perform their functional roles in the adaptation to niche and intra-cellular conditions.

Research   Open Access

Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli

W Nicholson Price, Samuel K Handelman, John K Everett, Saichiu N Tong, Ana Bracic, Jon D Luff, Victor Naumov, Thomas Acton, Philip Manor, Rong Xiao, Burkhard Rost, Gaetano T Montelione, John F Hunt Microbial Informatics and Experimentation 2011, 1:6 (27 June 2011)

Research   Open Access

The evolutionary rate variation among genes of HOG-signaling pathway in yeast genomes

Xuechang Wu, Xiaoqin Chi, Pinmei Wang, Daoqiong Zheng, Rui Ding, Yudong Li Biology Direct 2010, 5:46 (10 July 2010)

The evolutionary rates of genes in HOG-signaling pathway varied greatly across yeast species, and could be affected by functional constraints, pathway position, and other factors.

Hypothesis   Open Access

Genome factor and gene pleiotropy hypotheses in protein evolution

Yanwu Zeng, Xun Gu Biology Direct 2010, 5:37 (24 May 2010)

Research article   Open Access

An evolutionary and structural characterization of mammalian protein complex organization

Philip Wong, Sonja Althammer, Andrea Hildebrand, Andreas Kirschner, Philipp Pagel, Bernd Geissler, Pawel Smialowski, Florian Blöchl, Matthias Oesterheld, Thorsten Schmidt, Normann Strack, Fabian J Theis, Andreas Ruepp, Dmitrij Frishman BMC Genomics 2008, 9:629 (23 December 2008)