Figure 2.

RanGTP dependent karyopherin-RP dissociation reduces chimerism. (A) The geometry used for the simulations has no NE, chromosomes and mitochondria are in the cytoplasm. (B) Steady state distribution of RanGTP, RanGDP, karyopherin and karyopherin-RanGTP along the line shown in panel (A). (C) Steady state distribution of host-RP, mitochondrial-RP, karyopherin-host-RP and karyopherin-mitochondrial-RP complexes along the line shown in panel (A). (D) Chimerism (mitochondrial-RP/host-RP) at different values of the forward rate constant for the RanGTP driven host-RP-karyopherin dissociation reaction (host-RP-karyopherin + RanGTP => host-RP + karyopherin-RanGTP) along the line shown in panel (A).