Biology Direct

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The Last Universal Common Ancestor: emergence, constitution and genetic legacy of an elusive forerunner

Nicolas Glansdorff, Ying Xu and Bernard Labedan*

Biology Direct 2008, 3:29 doi:10.1186/1745-6150-3-29

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The fundamental units, processes and patterns of evolution, and the Tree of Life conundrum

Eugene V Koonin, Yuri I Wolf Biology Direct 2009, 4:33 (29 September 2009)

This article is part of a collection on Evolutionary Biology 150...

A tree is a natural representation of evolution owing to the inherent tree-like character of the replication process but the fundamental units of evolution amenable to tree analysis seem to be individual genetic elements rather than complete genomes.

Research   Open Access

Structural analysis of polarizing indels: an emerging consensus on the root of the tree of life

Ruben E Valas, Philip E Bourne Biology Direct 2009, 4:30 (25 August 2009)

This article is part of a collection on Evolutionary Biology 150...

The disparate rootings of the tree of life by Cavalier-Smith and Lake et al. converge on a single root when polarizable indels are analyzed using protein structure.

Hypothesis   Open Access

On the need for widespread horizontal gene transfers under genome size constraint

Hervé Isambert, Richard R Stein Biology Direct 2009, 4:28 (25 August 2009)

This article is part of a collection on Evolutionary Biology 150...

Research   Open Access Highly Accessed

On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth

Armen Y Mulkidjanian, Michael Y Galperin Biology Direct 2009, 4:27 (24 August 2009)

The relatively high zinc content of living cells and its role as cofactor in many key enzymes and RNA structures might reflect the origin of life in zinc-rich environments.