Biology Direct
Volume 3
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 Discovery notesAn intragenic distribution bias of DNA uptake sequences in Pasteurellaceae and NeisseriaeMark WJ van Passel  Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB, Wageningen, The Netherlands  author email corresponding author email
Biology Direct 2008,
3:12doi:10.1186/1745-6150-3-12 Abstract
Most sequenced strains from Pasteurellaceae and Neisseriae contain hundreds to thousands of uptake sequence (US) motifs in their genome, which are associated with natural competence for DNA uptake. The mechanism of their recognition is still unclear, and I searched for intragenic location patterns of these motifs for clues about their distribution. In all cases, one orientation of the US has a higher occurrence in the reading frame, and in all Pasteurellaceae, the US and the reverse complement motifs are biased towards the gene termini. These findings could help design experimental set-ups to study preferential DNA uptake, thereby further unravelling the phenomenon of natural competence.
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This article was reviewed by Arcady Mushegian and I. King Jordan. | 
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