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Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes

Natasha J Hill1,3 email, Aleksandr Stotland1 email, Michelle Solomon1 email, Patrick Secrest1 email, Elizabeth Getzoff2 email and Nora Sarvetnick1 email

Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA

Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Sciences, Barts and the London Queen Mary's School of Medicine and Dentistry, London, UK

author email corresponding author email

Biology Direct 2007, 2:5doi:10.1186/1745-6150-2-5

Published: 25 January 2007

Additional files

Additional File 1:

Chimerism data for the experiment in Figure 3D. This figure shows the %Thy1.1+ cells within CD4 and CD8 T cell populations for secondary lymphoid organs in irradiated Idd9 (circles) and NOD (filled diamonds) recipients. No difference in %Thy1.1 (donor) cells between Idd9 congenic and NOD recipients is observed.

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