Biology Direct

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Open Access Research

Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes

Natasha J Hill1,3, Aleksandr Stotland1, Michelle Solomon1, Patrick Secrest1, Elizabeth Getzoff2 and Nora Sarvetnick1*

Author Affiliations

1 Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

2 Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA

3 Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Sciences, Barts and the London Queen Mary's School of Medicine and Dentistry, London, UK

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Biology Direct 2007, 2:5 doi:10.1186/1745-6150-2-5

Published: 25 January 2007

Additional files

Additional File 1:

Chimerism data for the experiment in Figure 3D. This figure shows the %Thy1.1+ cells within CD4 and CD8 T cell populations for secondary lymphoid organs in irradiated Idd9 (circles) and NOD (filled diamonds) recipients. No difference in %Thy1.1 (donor) cells between Idd9 congenic and NOD recipients is observed.

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