Research
Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold
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* Corresponding author: L Aravind aravind@ncbi.nlm.nih.gov
1 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
2 Bioinformatics Program, Boston University, Boston, MA 02215, USA
Biology Direct 2007, 2:18 doi:10.1186/1745-6150-2-18
Published: 2 July 2007Additional files
Additional file 1:
β-grasp families: members, phyletic patterns, and selected alignments. A mega-alignment of several prokaryotic and eukaryotic β-GF lineages and alignments of all newly-identified β-grasp folds and novel ancillary domains are provided along with gi numbers of the sequences collected from iterative database searches and the phyletic pattern of each β-grasp family.
Format: TXT Size: 6.8MB Download file
Additional file 2:
Natural classification of the β-GF. Superfamilies/families/subfamilies of the β-GF are grouped according to shared structural and sequence features, indentations represent the inferred hierarchy of evolutionary relationships based on these features. Major shared features of a set of superfamilies are given between dashed lines and labeled with roman numerals. Superfamilies are written in bold text, with families and subfamilies written in bold, italicized text. Phyletic distribution of a family/subfamily are given in parentheses after name. Brief description of functional role is given following phyletic distribution where known. Selected PDB identifiers of solved crystal structures are indented and listed underneath family/superfamily.
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