Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
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* Corresponding author: Frances H Arnold frances@cheme.caltech.edu
Biology Direct 2007, 2:17 doi:10.1186/1745-6150-2-17
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Research article
Evolution favors protein mutational robustness in sufficiently large populations Jesse D Bloom, Zhongyi Lu, David Chen, Alpan Raval, Ophelia S Venturelli, Frances H Arnold BMC Biology 2007, 5:29 (17 July 2007) Mutational changes with no functional benefit, that may lend themselves to protein evolvability, nevertheless are selected for in larger experimental populations of neutrally evolved cytochrome P450 proteins independent of selection for thermodynamic stability.
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