Protecting exons from deleterious R-loops: a potential advantage of having introns
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Correspondence: Deng-Ke Niu dkniu@bnu.edu.cn
Biology Direct 2007, 2:11 doi:10.1186/1745-6150-2-11
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Research
Genome-wide functional analysis of human 5' untranslated region introns Can Cenik, Adnan Derti, Joseph C Mellor, Gabriel F Berriz, Frederick P Roth Genome Biology 2010, 11:R29 (11 March 2010) Genes with short 5'UTR introns have higher expression than genes with no or long 5'UTR introns. Complex evolutionary forces act on these introns. |
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Research article
Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigas Paulina Schmitt, Yannick Gueguen, Erick Desmarais, Evelyne Bachère, Julien de Lorgeril BMC Evolutionary Biology 2010, 10:23 (25 January 2010) |
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Hypothesis
Exon definition as a potential negative force against intron losses in evolution Deng-Ke Niu Biology Direct 2008, 3:46 (13 November 2008) If the splicing of pre-mRNAs is initiated by exon definition, an exon larger than a particular size may cause splicing errors . Intron loss that results in oversized exons may thus be deleterious and selected against.
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Research article
Evidence against the energetic cost hypothesis for the short introns in highly expressed genes Yi-Fei Huang, Deng-Ke Niu BMC Evolutionary Biology 2008, 8:154 (20 May 2008) |