Table 1 |
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Proteins localized in the peroxisome in S. cerevisiae and R. norvegicus. Gene names are from SGD, Swissprot or GeneBank. Proteins in the same row are orthologous to each other, whenever there is a "one to many" orthology relationship this is indicated by boxes containing several rows. Absence of the gene or absence of evidence of a peroxisomal localization of the encoded protein is indicated by a dash. Proteins that show homology with components of the ERAD pathways are indicated with names in bold and a comment indicating that homology. For each orthologous group, the annotated function and the phylogenetic origin is indicated (euk: eukaryotic no bacterial homologs; euk (a.o.): presence of bacterial homologs but the phylogenetic reconsructions indicates an ancient origin derived from the common ancestor of eukaryotes and archaea; alpha: alpha-proteobacterial origin; actinomyc.: derived from the actinomycetales; cyanobac.: cyanobacterial origin; u, unresolved phylogenetic origin. |
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| S. cerevisiae |
R. norvegicus |
Origin |
Function (comment) |
|
|
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| PEX1 |
PEX1 |
euk (a.o) |
Peroxisome organization and biogenesis (Homologous to ERAD protein Cdc48) |
| PEX2 |
PEX2 |
euk |
Peroxisome organization and biogenesis (Homologous to ERAD protein Hrd1) |
| PEX3 |
PEX3 |
euk |
Peroxisome organization and biogenesis |
| PEX4 |
PEX4 |
Euk |
Peroxisome organization and biogenesis (Homologous to ERAD protein Ubc1) |
| PEX5 |
PEX5 |
euk (a.o) |
Peroxisome organization and biogenesis (Homologous to ERAD protein Hrd3) |
| PEX6 |
PEX6 |
euk (a.o) |
Peroxisome organization and biogenesis |
| PEX7 |
PEX7 |
Euk |
Peroxisome organization and biogenesis |
| PEX8 |
- |
Euk |
Peroxisome organization and biogenesis |
| PEX10 |
PEX10 |
Euk |
Peroxisome organization and biogenesis (Homologous to ERAD protein Hrd1) |
| - |
PEX11 |
euk (a.o) |
Peroxisome organization and biogenesis |
| PEX12 |
PEX12 |
euk |
Peroxisome organization and biogenesis |
| PEX13 |
PEX13 |
euk |
Peroxisome organization and biogenesis |
| PEX14 |
PEX14 |
euk (a.o) |
Peroxisome organization and biogenesis |
| PEX15 |
- |
euk |
Peroxisome organization and biogenesis |
| - |
PEX16 |
euk |
Peroxisome organization and biogenesis |
| PEX17 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX18 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX19 |
PEX19 |
euk |
Peroxisome organization and biogenesis |
| PEX21 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX22 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX25 |
- |
euk |
Peroxisome organization and biogenesis |
| - |
PEX26 |
euk |
Peroxisome organization and biogenesis |
| PEX27 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX28 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX29 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX30 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX31 |
- |
euk |
Peroxisome organization and biogenesis |
| PEX32 |
- |
euk |
Peroxisome organization and biogenesis |
| ANT1 |
PMP34 |
euk |
Adenine nucleotide transporter |
| - |
PMP24 |
euk |
Peroxisomal membrane protein |
| - |
PMP22 |
euk |
Peroxisomal membrane protein |
| - |
PAHX |
U |
Phytanoyl-CoA dioxygenase |
| - |
gi-6912418 |
U |
2-hydroxyphytanoyl-CoA lyase |
| - |
PTE2B |
alpha |
peroxisomal long chain acyl-CoA thioesterase Ib |
| TES1 |
PTE1_MOUSE |
alpha |
Peroxisomal acyl-coenzyme A thioester hydrolase 1 |
| CTA1 |
CATALASE |
euk (a.o) |
Catalase A |
| FOX1 |
OXRTA2 |
U |
acyl-CoA oxidase |
| gi-1684747 |
U |
||
| CAO3_RAT |
U |
||
| FOX2 |
gi-13242303 |
alpha |
peroxisomal multifunctional beta-oxidation protein |
| gi-4105269 |
alpha |
putative peroxisomal 2,4-dienoyl-CoA reductase |
|
| gi-5052204 |
alpha |
putative short-chain dehydrogenase/reductase |
|
| FOX3 |
gi-6978429 |
U |
peroxisomal 3-oxoacyl CoA thiolase |
| - |
ECHP_RAT |
U |
Peroxisomal bifunctional enzyme |
| - |
SCP2 |
U |
sterol carrier protein-2 |
| IDP3 |
gi-13928690 |
U |
Peroxisomal NADP-dependent isocitrate dehydrogenase |
| ECI1 |
gi-6755026 |
alpha |
enoyl-CoA isomerase |
| DCI1 |
alpha |
||
| - |
BAAT |
alpha |
bile acid-Coenzyme A: amino acid N-acyltransferase |
| - |
gi-12002203 |
actinomyc. |
alkyl-dihydroxyacetonephosphate synthase |
| - |
DAPT_RAT |
actinomyc. |
Dihydroxyacetone phosphate acyltransferase |
| - |
AGT |
cyanobac. |
alanine-glyoxylate aminotransferase |
| - |
gi-6679507 |
U |
pipecolic acid oxidase |
| - |
URIC_RAT |
U |
Urate oxidase |
| PXA1 |
PMP70 |
U |
fatty acid transport |
| ALDP |
U |
ATP-binding cassette |
|
| ALDPR |
U |
ATP-binding cassette |
|
| FAA1 |
- |
euk |
|
| FAA2 |
LCF2 |
U |
Long-chain-fatty-acid--CoA ligase |
| LACS |
U |
||
| FAT1 |
VLACS |
U |
Fatty acid transport |
| - |
gi-14091775 |
U |
Hydroxyacid oxidase 3 (medium-chain) |
| - |
gi-6754156 |
U |
Hydroxyacid oxidase 1 |
| - |
GTK1_RAT |
U |
Glutathyhion-S transferase |
| - |
AMCR |
U |
2-arylpropionyl-CoA epimerase |
| - |
FIS1 |
euk |
Peroxisome fission |
| FAT2 |
- |
alpha |
probable AMP-binding protein |
| CIT2 |
- |
U |
Citrate synthase |
| GPD1 |
- |
alpha |
glycerol-3-phosphate dehydrogenase |
| MDH3 |
- |
U |
malate dehydrogenase |
| LYS1 |
- |
euk |
Lysine biosynthesis, saccharopine dehydrogenase |
| LYS4 |
- |
U |
Lysine biosynthesis |
| PNC1 |
- |
U |
NAD(+) salvage pathway |
| NPY1 |
- |
alpha |
NADH diphosphatase (pyrophosphatase) |
| STR3 |
- |
U |
Sulfur Transfer |
| YGR154C |
- |
U |
|
| MLS1 |
- |
U |
Malate synthase 1 |
| MLS2 |
- |
U |
Malate synthase 2 |
| EMP24 |
- |
euk |
Vesicle organization and biogenesis |
| ERG1 |
- |
U |
Ergosterol biosynthesis |
| ERG6 |
- |
U |
Ergosterol biosynthesis |
| RHO1 |
- |
euk |
GTP-binding protein |
| SPS19 |
- |
U |
2,4-dienoyl-CoA reductase |
| YOR084W |
- |
euk |
Peroxisome organization and biogenesis |
| YMR204C |
- |
euk |
|
| CAT2 |
- |
euk |
Carnitine acetyltransferase |
| PCD1 |
- |
alpha |
Nudix hydrolase |
| AAT2 |
- |
euk |
Aspartate aminotransferase |
| PXA2 |
- |
U |
Peroxisomal ATP-binding cassette, fatty acid transport |
| VPS1 |
- |
euk |
Dynamin 1 |
|
|
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Gabaldón et al. Biology Direct 2006 1:8 doi:10.1186/1745-6150-1-8 |
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