Biology Direct

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A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

Kira S Makarova1, Nick V Grishin2, Svetlana A Shabalina1, Yuri I Wolf1 and Eugene V Koonin1*

Author Affiliations

1 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

2 Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA

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Biology Direct 2006, 1:7 doi:10.1186/1745-6150-1-7

Published: 16 March 2006

Additional files

Additional file 1:

GI number for all families of Cas proteins.

Format: XLS Size: 85KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

multiple protein sequence alignment for COG1343.

Format: TXT Size: 22KB Download file

Open Data

Additional file 3:

multiple protein sequence alignment for COG1857.

Format: TXT Size: 36KB Download file

Open Data