|
NSMC and NSCS test results for TP53 somatic mutation spectra (H0: mutational bias; H1: selectional bias) |
||||
| Sites |
Mutations |
Hotspots |
P(H1)/χ2 |
|
|
|
||||
| Bladder |
||||
| Synonymous |
61 |
80 |
12 |
|
| Non-synonymous |
240 |
775 |
110 |
0.107/13.8 |
| Nonsense |
36 |
85 |
26 |
0.038 |
| Brain |
||||
| Synonymous |
20 |
23 |
2 |
|
| Non-synonymous |
199 |
812 |
98 |
0.998/11.2 |
| Nonsense |
14 |
32 |
5 |
0.015 |
| Breast |
||||
| Synonymous |
77 |
108 |
19 |
|
| Non-synonymous |
294 |
1423 |
171 |
0.111/27.3 |
| Nonsense |
49 |
73 |
27 |
0.052 |
| Liver |
||||
| Synonymous |
34 |
43 |
5 |
|
| Non-synonymous |
199 |
727 |
99 |
0.980/14.4 |
| Nonsense |
29 |
50 |
16 |
0.040 |
| Lung |
||||
| Synonymous |
56 |
88 |
17 |
|
| Non-synonymous |
314 |
1599 |
191 |
0.959/17.9 |
| Nonsense |
55 |
170 |
31 |
0.042 |
| Pancreas |
||||
| Synonymous |
10 |
12 |
1 |
|
| Non-synonymous |
106 |
215 |
30 |
0.049/1.56 |
| Nonsense |
10 |
17 |
6 |
0.058 |
| Ovary |
||||
| Synonymous |
20 |
21 |
1 |
|
| Non-synonymous |
192 |
770 |
99 |
0.995/15.7 |
| Nonsense |
30 |
71 |
12 |
0.012 |
| Prostate |
||||
| Synonymous |
28 |
38 |
7 |
|
| Non-synonymous |
114 |
195 |
38 |
0.926/0.72 |
| Nonsense |
9 |
12 |
2 |
0.008 |
| Colon |
||||
| Synonymous |
23 |
28 |
4 |
|
| Non-synonymous |
173 |
592 |
69 |
1.000/4.4 |
| Nonsense |
19 |
60 |
5 |
0.016 |
| Colorectal |
||||
| Synonymous |
25 |
28 |
4 |
|
| Non-synonymous |
203 |
1097 |
121 |
0.000/20.3 |
| Nonsense |
29 |
103 |
12 |
0.953 |
| Esophagus |
||||
| Synonymous |
25 |
32 |
7 |
|
| Non-synonymous |
215 |
1064 |
117 |
0.025/6.26 |
| Nonsense |
50 |
150 |
27 |
0.032 |
| Hematopoietic |
||||
| Synonymous |
26 |
29 |
3 |
|
| Non-synonymous |
202 |
723 |
99 |
0.037/13.08 |
| Nonsense |
20 |
37 |
5 |
0.018 |
| Larynx |
||||
| Synonymous |
8 |
10 |
2 |
|
| Non-synonymous |
108 |
234 |
42 |
1.000/0.60 |
| Nonsense |
18 |
24 |
5 |
0.007 |
| Mouth |
||||
| Synonymous |
28 |
41 |
9 |
|
| Non-synonymous |
176 |
413 |
79 |
0.988/1.59 |
| Nonsense |
33 |
53 |
10 |
0.901 |
| Skin |
||||
| Synonymous |
64 |
136 |
12 |
|
| Non-synonymous |
248 |
563 |
99 |
0.931/9.94 |
| Nonsense |
25 |
69 |
12 |
0.025 |
| Stomach |
||||
| Synonymous |
44 |
64 |
15 |
|
| Non-synonymous |
195 |
617 |
88 |
0.115/1.78 |
| Nonsense |
21 |
52 |
8 |
0.029 |
|
In the last column, the P-value for the NSMC test (numerator) and the χ2 value for the NSCS test (denominator) are shown along with the NSMC test P-value for the hotspots in nonsense sites. The statistically significant values (rejection of H0) are shown in bold type. | ||||
Glazko et al. Biology Direct 2006 1:4 doi:10.1186/1745-6150-1-4 |
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