Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection

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Galina V Glazko, Vladimir N Babenko, Eugene V Koonin^* and Igor B Rogozin^*

* Corresponding authors: Eugene V Koonin koonin@ncbi.nlm.nih.gov - Igor B Rogozin rogozin@ncbi.nlm.nih.gov

Biology Direct 2006, 1:4 doi:10.1186/1745-6150-1-4