Research

Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection

Galina V Glazko¹, Vladimir N Babenko², Eugene V Koonin²^* and Igor B Rogozin²^*

* Corresponding authors: Eugene V Koonin koonin@ncbi.nlm.nih.gov - Igor B Rogozin rogozin@ncbi.nlm.nih.gov

¹ Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA

² National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

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Biology Direct 2006, 1:4 doi:10.1186/1745-6150-1-4

Published: 31 January 2006

Additional File 1:

NSMC test results for the p53 spectra with CpG sites removed (H0: mutational bias; H1: selectional bias).

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Additional File 2:

NSMC test results for combined spectra for the 4 analyzed tumor suppressors^a.

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Additional File 3:

Hotspots non-randomly associate with non-synonymous sites according to the NSB test.

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