Figure 1.

Evolutionary conservation of the SecY channel. Structure of the Methanococcus jannaschii SecY protein with sequence conservation mapped onto it. Conservation scores for SecY were calculated using the ConSurf server [22-24] based on a multiple alignment of 23 archaebacterial, 25 eukaryotic and 24 eubacterial SecY sequences. The conservation scores were displayed on the structure of SecY from Methanococcus jannaschii [15] (PDB code 1RH5) using Pymol [25] and the color_b.py script [26]. A) and B) are lateral views from the plane of the membrane, C) and D) are cytoplasmic views. B) and D) are sectioned at the middle of the molecule.