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Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus

Yuri I Wolf1 email, Cecile Viboud2 email, Edward C Holmes2,3 email, Eugene V Koonin1 email and David J Lipman1 email

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA

Fogarty International Center, National Institutes of Health, Bethesda, MD, USA

Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA, USA

author email corresponding author email

Biology Direct 2006, 1:34doi:10.1186/1745-6150-1-34

Published: 26 October 2006

Additional files

Additional file 1:

Multiple alignment of influenza virus sequences. Multiple alignments of H3N2 HA, H3N2 PA and H1N1 HA coding sequences and H3N2 HA amino acid sequences with antigenic epitopes mapped in aligned FASTA format.

Format: TXT Size: 4.4MB Download file


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