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Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons

Pavel V Baranov email, Bente Vestergaard email, Thomas Hamelryck email, Raymond F Gesteland email, Jens Nyborg^ and John F Atkins email

Biology Direct 2006, 1:28doi:10.1186/1745-6150-1-28

Class-I release factors lacking the domain 1.

Pavel Baranov   (01 November 2006)  University College Cork

This is a comment by an author who wish to mention recently published data relevant to this article.

A paper describing the complete genome of the bacterial endosymbiont Carsonella ruddii has been published in Science on the 13th of October (Nakabachi et al. 2006. Science 314:267). Apparently, the class-I release factors from this specie lack the domain 1. RF1 omits it entirely, while in RF2, if it exists, it is significantly truncated. This further underpins the idea discussed in this manuscript that the domain 1 is not obligatory in bacterial class-I RFs.

It is worth noticing that C. ruddii RFs have unusual “tripeptide anticodons”, PKS in RF1 and NPL in RF2.

Competing interests

none

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